The endothelium is the inner lining of the blood vessel that regulates arterial health. Maintaining its youthful integrity supports overallcardiovascular health as humans age.

Endothelial Defense™ with Full-Spectrum Pomegranate™ supplies standardized pomegranate and an orally active form of superoxide dismutase to support endothelial health. Both of these components (pomegranate, SOD) have been clinically shown to help with blood flow and age-related changes in endothelial function.2-8

1. Pomegranate supports healthy blood flow. In a group of aging humans with risk factors for cardiovascular events, pomegranate or placebo was ingested on a daily basis. After 12 months, the mean intima media thickening improved 44% in the pomegranate group, whereas carotid blood flow worsened by 9% in the placebo group.2 Both groups continued taking conventionally prescribed medications. In another study on patients with ischemic coronary heart disease, pomegranate or placebo was ingested daily. After only three months, coronary artery blood flow improved by 18% in the pomegranate group, but worsened by 17% in the placebo group.2 A standardized pomegranate extract is one of the active components of Endothelial Defense™.
2. SOD protects against nitric oxide degradation. Aging results in a reduction of our body’s production of the critical antioxidant called superoxide dismutase (SOD). One consequence of SOD depletion is excess degradation of endothelial nitric oxide. An orally active superoxide dismutase called GliSODin® has been clinically shown to support healthy arterial function and structure … while boosting levels of the body’s most powerful antioxidant enzymes (SOD and catalase).4-7 Studies show that carotid artery thickness increases by 0.04 mm every 10 years. However, a 2007 GliSODin® study suggested that 2.8 years of supplementation may turn back the clock on 10 years of age-related changes due to carotid artery wall thickening.6Endothelial Defense™ contains the patented GliSODin® in the identical dose.
3. Pomegranate flower extract and seed oil blend. This blend of pomegranate flower extract and seed oil contains potent polyphenols that provide support for youthful lipid and glucose metabolism and help with inflammatory factors.8 

POMELLA® Extract is covered under U.S. Patent 7,638,640 and POMELLA® is a registered trademark of Verdure Sciences, Inc. 
Isocell SA, France is the owner of US Patents Nos. 6,045,809 and 6,426,068B1 and trademark of GliSODin®.